I have made remarks here on my blog about CRISPR gene technology as well as a few posts on gene editing and its relevance to modern agriculture and science in general. I think it is a marvellous technology tool with enormous potential for variety improvement in agriculture.
A recent post highlighted the fact that the USDA has concluded that using CRISPR gene editing is not the same as creating GMO varieties - as no transgenic change occurs. This allows a less ardous pathway to commercial use for new products developed through this technology, as they are not GMOs.
The comment below by Bill Gates [the one from Microsoft!] might have more clout than me, but he is a strong supporter of genetic improvements across a wide field and now has close contact with eminent researchers through heading the Bill and Melinda Gates Foundation which supports international research and development. And he supports CRISPR work generally.
It is worth reading..........
link below:
https://www.foreignaffairs.com/articles/2018-04-10/gene-editing-good?cid=nlc-emc-paywall-free-reading-bill-gates-a-20180411
Showing posts with label gene technology. Show all posts
Showing posts with label gene technology. Show all posts
Thursday, April 12, 2018
Wednesday, January 18, 2017
‘Gene-silencing’ technique - game-changer for crop protection?
Researchers at the University of Surrey and University of Queensland have developed a revolutionary new crop protection technique which offers an environmentally-friendly alternative to genetically-modified crops and chemical pesticides.
The breakthrough research, published in Nature Plants, could have huge benefits for agriculture and positively impact communities around the world. Plant pests and pathogens are estimated to reduce global crop yields by 30 to 40 per cent a year, constraining global food security. At the same time, the need for higher production, regulatory demands, pesticide resistance, and concern about global warming driving the spread of disease all mean there is a growing need for new approaches to crop protection.
The researchers have found that by combining clay nanoparticles with designer ‘RNAs’ (molecules with essential roles in gene biology), it is possible to silence certain genes within plants. The spray they have developed – known as BioClay – has been shown to give plants virus protection for at least 20 days following a single application. When sprayed with BioClay, the plant ‘thinks’ it is being attacked by a disease or pest insect and responds by protecting itself. With virus diseases commonplace in many field crop and vegetable crops, this could be a huge breakthrough - essentially immunising plants when a disease threatens.
The latest research overcomes the instability of ‘naked’ RNAs sprayed on plants, which has previously prevented them from being used effectively for virus protection. By loading the agents on to clay nanoparticles, they do not wash off, enabling them to be released over an extended period of time before degrading.
The BioClay technology, which is based on nanoparticles used in the development of human drug treatments, has a number of advantages over existing chemical-based pesticides. Since BioClay is non-toxic and degradable, there is less risk to the environment and human health. It can also be used in a highly targeted way to protect crops against specific pathogens.
Professor G.Q. Max Lu, President and Vice-Chancellor of the University of Surrey and co-author of the research paper, said: “This is one of the best examples of nanoparticles being effective for biological molecular delivery with a controlled release rate for combating diseases in plants or animals. The same nanoparticle technology invented and patented in my laboratory at the University of Queensland was used for effective targeted drug delivery. It was licensed to an Oxford-based pharmaceutical company and is now being commercialised for drug development.”
“I am very pleased to see the exciting results of this project and the publication of our research in the prestigious Nature Plants journal.”
The research paper, ‘Clay nanosheets for stable delivery of RNA interference as a topical application to protect plants against viruses’ is published in Nature Plants on 10 January 2017.
The research was led by researchers Professor Neena Mitter and Professor Gordon Xu at the University of Queensland in collaboration with Professor Lu of the University of Surrey.
While field trials been conducted successfully, a lot more field and lab research will be needed to reach the goal of regulatory approvals and have the technique used widely.
More at http://www.fatcow.com.au/articles/news/gene-silencing-technique-is-a-game-changer-for-crop-protection-n2526805#MdQxQZIhvP18Vgci.99
Tuesday, November 04, 2014
Cannot Stop the Advance of GM Technology
The former secretary of both the Australian agriculture and transport departments made the no-nonsense observation in a detailed outline of global and domestic attitudes on biotechnology at the National Farmers' Federation Congress in Canberra last week.
Mr Matthews summed up by saying Australia suffers from not having a more objective, science-based discussion about agricultural biotechnology. “It’s really important that Australia has practicing farmers speak up for agricultural biotechnology because it’s practicing farmers that will be persuasive.” The ongoing anti-GM campaign is one of the “big risks” facing the technology’s development, he said.
“There is a great suspicion of science and scientists in public debate in Australia and there has been a very effective campaign by NGOs (non-government organisations) which has influenced public opinion.
“As a result, what worries me is that environmentally responsible farmers - who tend in many other areas to be leaders of farm opinion - can often be ambivalent about GM. “The pro-GM constituency among farmers is therefore not as strong as it could be in Australia.”
Governments need to lead
Mr Matthews said attitudes held by the general public, consumers, environmentalists and media were also central problems in the GM debate.
But his strongest criticism was reserved for various governments that refuse to allow GM crops to be cultivated, despite overwhelming scientific evidence.
“Some governments in Australia are – and I use this word carefully – gutless,” he said.
“There are total bans on GM in South Australia, Tasmania and the ACT,” he said.
“There are moratoriums in WA and NSW but there are certainly exemptions for that. In my view they (total bans) aren’t rationally based; they aren’t properly founded in science.
“Those moratoria need to be ended and we need to avoid further mandatory labelling requirements, unless they can be justified.”
Hinting at the recent high profile legal case involving neighbouring organic and GM farmers, Steve Marsh and Mike Baxter in Kojonup WA, Mr Matthews said the problem with reconciling organic standards and GM crops also “needs to be tackled”.
He said there were three inescapable truths about biotechnology: the first being that it provides a critical opportunity to lift the productivity, profitability and sustainability of Australian agriculture over the next 20 years.
Secondly, he said biotechnology was critical to meeting rapidly rising global food needs.
And thirdly, biotechnology will inevitably continue to attract “suspicion and opposition” in some community sectors, slowing its development.
Mr Matthews said that opposition was based on four key concerns: food safety; environmental damage; “agrochemical industry domination” and “a roundup of ethical and religious issues”.
However, he said science delivered a very clear message about the safety of GM technology.
GM safety scientifically proven
Mr Matthews said more than 100 of the world’s independent science oversight bodies, including “very authoritative and credible organisations” in the US and Europe, shared a consensus that GM crops are “as safe as conventional varieties - and often safer because of the extensive approval process they need to go through”. “The scientific evidence is overwhelmingly in favour of GM safety, assuming that we continue with the sound regulatory processes that we have,” he said. “There have now been 3 trillion meals (consumed) involving or including GM and there’s been not one recorded case of harm. “There have been 70 billion animals which have been feeding on GM feed of some sort, and not one recorded case of harm.”
Mr Matthews said a recent European review of over 1700 scientific studies around the world about environmental impacts of GM concluded that there was little or no evidence GM crops caused negative environmental impacts.
“To me, as a student of public policy, it’s really interesting that the environment movement is very keen for science to be heard in the climate change debate - but where the science is very clear, no one seems to want to know about biotechnology,” he said.
Mr Matthews faced a question from the floor at the NFF Congress from NSW Farmers executive councillor Gai Marshall, referring to the controversial Seralini rat study on GM corn, which purported to find the GM feed caused tumour growth. Ms Marshall said she wasn’t against growing GM but wanted to see greater traceability.
Mr Matthews said the Seralini piece of science had been retracted. “It has been rejected, it has been withdrawn,” he said. “The peer review, the second time around, found it totally discredited.”
A solution to global food security?
Mr Matthews said the problems GM could solve were “unprecedented in history”.
He said there are huge farm business opportunities from potential GM products like self-fertilising plants that could “revolutionise agriculture and certainly would decouple agriculture from the oil industry”.
GM crops also had a key role to play in aiding the future food demand task as the world’s population grows from 7.2 billion now to 9.6 billion by 2050, with decreasing land and water to develop globally - 800 million people already go to bed hungry each night and 1 billion people are chronically undernourished, he said.
“In the meantime, if I can be a bit provocative, there are some pretty comfortable western based NGOs which continue to oppose and to slow down biotechnology, on non-scientific, without evidence grounds,” he said.
Mr Matthews said a striking example of that argument was the fact 250 million children are currently suffering from vitamin A deficiency but GM food crops with existing solutions “are having trouble getting mobilised”. “Norman Borlaug, said to be the father of the green revolution, said once that if the naysayers do stop agricultural GM they might actually precipitate those famines and crises they’ve been predicting for years,” he said.
Mr Matthews said the technology’s uptake was unprecedented, with 79 per cent of global soybean area and 70pc of global cotton area now GM. “Growers are certainly not changing their mind and going back after they trial GM,” he said.
“Over the last 200 years there have been several waves of innovation in agriculture such as mechanisation, conventional plant breeding, chemical fertilisers and chemical herbicides.
“But none of them has been adopted as rapidly as GM seeds and I can tell you that animal-based GM is coming up very fast behind them. “One eighth of global farm land is now GM, so this is a sort of mega bus that will not be stoppable.”
Mr Matthews said GM offers varieties with production benefits like faster growth rates and yields, drought tolerance, pesticide reduction and nutrient efficiency.
He said exciting work is also happening to generate varieties with consumer and health benefits like foods with fewer saturated fats, zero allergens, increased dietary fibre, reduced natural toxins, higher protein levels, built in vaccines, cholesterol management, and vitamin A.
“Benefits do flow to big biotech companies but perversely the regulatory costs - as a consequence of pressure from the opponents of GM - now make approvals just out of reach for anyone but the big firms,” he said. “As an example, a single new GM trait may now cost $139 million, including $35 million just for the approvals part of that, and around the world it takes five-and-a-half years on average to gain a single new approval.
“Are those costs and time problems squeezing out public good innovations such as environmental public health innovations or small market GM innovations?”
Need to build trust
Mr Matthews said Australia grew GM canola and GM cotton and had great strengths in the area, with a world class regulatory system and plant breeding expertise.
But he said a three-part plan was needed to help overcome the slow progress of biotechnology development.
He said a constituency of biotechnology supporters was needed to build understanding of the potential benefits to farmers, consumers, the environment and society as a whole. “We need to build community confidence and trust in Australia’s regulatory arrangements,” he said. “We do need to be respectful of ethical concerns about biotechnology, but at the same time we need to give voice to the beneficiaries, and I think of those kids in Africa.
“When people are talking grandly about ethical concerns about biotechnology I worry about starving kids in Africa. “We need to focus research more on benefits to consumers, to the environment, to society and we need to find some champions.”
[ based on an article in the online edition of Qld Country Life 4 Nov 2014]
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